1Sauté diced onion and minced garlic in a skillet until softened and set aside to cool.
2Combine ground beef, crushed stuffing mix, eggs, milk, Cajun seasoning, Worcestershire sauce, and sautéed onions and garlic in a large bowl and mix until well combined.
3Transfer meat mixture to a baking dish and shape into a loaf.
4Mix ketchup, barbecue sauce, brown sugar, and mustard (if using) in a small bowl.
5Spread half of the sauce over the meatloaf and reserve the rest for dipping.
6Bake at 375°F for about 1 hour, or until the internal temperature reaches 160°F.