1Preheat oven to 375F. Line a 12-count muffin tin with muffin liners.
2Make the cream cheese filling: In a large bowl using a handheld mixer or stand mixer, combine sugar, softened cream cheese, egg, and vanilla extract. Beat until smooth and creamy.
3Make muffins: In a large bowl, whisk together melted butter, sugars, egg, milk, vanilla, and pumpkin. Add sifted flour, baking powder, baking soda, cinnamon, ginger, nutmeg, cloves, allspice, and salt. Mix with a wooden spoon or spatula until just combined.
4Fill prepared muffin liners with pumpkin muffin batter.
5Scoop cream cheese filling into a piping bag or ziptop bag with one corner snipped off. Insert into the center of the muffin and squeeze to fill, pulling the bag up and out while squeezing.
6Bake in preheated oven for 15-20 minutes, or until a toothpick inserted comes out clean.
7Cool 5 minutes in muffin tin, then remove to wire cooling rack.