1Trim the exterior fat from a flat cut brisket and slice it into small chunks.
2In a slow cooker, combine the brisket with red enchilada sauce, fire-roasted tomatoes, chipotle peppers, green chilies, honey, salt, onion powder, and black pepper. Mix well.
3Cook on high for 4-5 hours or on low for 5-6+ hours.
4Shred the brisket in the slow cooker and mix well.
5Add half-cooked pasta shells to the slow cooker and mix.
6Pour the blended queso sauce (made with cottage cheese, American cheese, extra sharp cheddar cheese, red enchilada sauce, nutritional yeast, salt, and pepper) over the pasta and brisket mixture.
7Stir everything together, cover, and cook on high for 20-25 minutes to allow the pasta to finish cooking and the sauce to thicken.